Reactive Oxygen Species-Triggered Trophoblast Apoptosis Is Initiated by Endoplasmic Reticulum Stress via Activation of Caspase-12, CHOP, and the JNK Pathway in Toxoplasma gondii Infection in Mice

Toxoplasma gondii infection in pregnant women may result in abortion or in fetal teratogenesis; however, the underlying mechanisms are still unclear. In this paper, based on a murine model, we showed that maternal infection with RH strain T. gondii tachyzoites induced elevated production of reactive...

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Detalhes bibliográficos
Main Authors: Xu, Xiucai, Liu, Tingting, Zhang, Aimei, Huo, Xingxing, Luo, Qingli, Chen, Zhaowu, Yu, Li, Li, Qing, Liu, Lili, Lun, Zhao-rong, Shen, Jilong
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
Assuntos:
Host Response and Inflammation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3370585/
https://ncbi.nlm.nih.gov/pubmed/22473610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.06295-11
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