A liquid chromatography/tandem mass spectrometry method for measuring the in vivo incorporation of plasma free fatty acids into intramyocellular ceramides in humans

RATIONALE: Sphingolipids are important components of cell membranes that serve as cell signaling molecules; ceramide plays a central role in sphingolipid metabolism. De novo ceramide biosynthesis depends on fatty acid availability, but whether muscle uses circulating free fatty acids or pre-existing...

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Main Authors: Blachnio-Zabielska, Agnieszka U., Persson, Xuan-Mai T., Koutsari, Christina, Zabielski, Piotr, Jensen, Michael D.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3370409/
https://ncbi.nlm.nih.gov/pubmed/22467464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/rcm.6216
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