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Inclusion of Gene-Gene and Gene-Environment Interactions Unlikely to Dramatically Improve Risk Prediction for Complex Diseases

Genome-wide association studies have identified hundreds of common genetic variants associated with the risk of multifactorial diseases. However, their impact on discrimination and risk prediction is limited. It has been suggested that the identification of gene-gene (G-G) and gene-environment (G-E)...

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Detalhes bibliográficos
Main Authors: Aschard, Hugues, Chen, Jinbo, Cornelis, Marilyn C., Chibnik, Lori B., Karlson, Elizabeth W., Kraft, Peter
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3370279/
https://ncbi.nlm.nih.gov/pubmed/22633398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2012.04.017
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