Allosteric Regulation of GRASP Protein-dependent Golgi Membrane Tethering by Mitotic Phosphorylation

Mitotic phosphorylation of the conserved GRASP domain of GRASP65 disrupts its self-association, leading to a loss of Golgi membrane tethering, cisternal unlinking, and Golgi breakdown. Recently, the structural basis of the GRASP self-interaction was determined, yet the mechanism by which phosphoryla...

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Bibliographic Details
Main Authors: Truschel, Steven T., Zhang, Ming, Bachert, Collin, Macbeth, Mark R., Linstedt, Adam D.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2012
Subjects:
Membrane Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3370171/
https://ncbi.nlm.nih.gov/pubmed/22523075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.326256
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