Protein Disulfide Isomerase Regulates Endoplasmic Reticulum Stress and the Apoptotic Process during Prion Infection and PrP Mutant-Induced Cytotoxicity

BACKGROUND: Protein disulfide isomerase (PDI), is sorted to be enzymatic chaperone for reconstructing misfolded protein in endoplasmic reticulum lumen. Recently, PDI has been identified as a link between misfolded protein and neuron apoptosis. However, the potential for PDI to be involved in the pat...

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Main Authors: Wang, Shao-Bin, Shi, Qi, Xu, Yin, Xie, Wu-Ling, Zhang, Jin, Tian, Chan, Guo, Yan, Wang, Ke, Zhang, Bao-Yun, Chen, Cao, Gao, Chen, Dong, Xiao-Ping
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3369880/
https://ncbi.nlm.nih.gov/pubmed/22685557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0038221
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