Plakophilin3 Loss Leads to an Increase in PRL3 Levels Promoting K8 Dephosphorylation, Which Is Required for Transformation and Metastasis

The desmosome anchors keratin filaments in epithelial cells leading to the formation of a tissue wide IF network. Loss of the desmosomal plaque protein plakophilin3 (PKP3) in HCT116 cells, leads to an increase in neoplastic progression and metastasis, which was accompanied by an increase in K8 level...

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Main Authors: Khapare, Nileema, Kundu, Samrat T., Sehgal, Lalit, Sawant, Mugdha, Priya, Rashmi, Gosavi, Prajakta, Gupta, Neha, Alam, Hunain, Karkhanis, Madhura, Naik, Nishigandha, Vaidya, Milind M., Dalal, Sorab N.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2012
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3368841/
https://ncbi.nlm.nih.gov/pubmed/22701666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0038561
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