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The TBX21 transcription factor T-1993C polymorphism is associated with decreased IFN-γ and IL-4 production by primary human lymphocytes

T-bet is a transcription factor that drives the Th1 immune response primarily through promoting expression of the IFN-γ gene. Polymorphisms in the T-bet gene, TBX21, have been associated with immune-mediated diseases such as asthma and systemic sclerosis. We found that the TBX21 promoter polymorphis...

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Main Authors: Fyall, K.M., Fong, A.M., Rao, S.B., Ibrahim, J.G., Waxweiler, W.T., Thomas, N.E.
Formato: Artigo
Idioma:Inglês
Publicado: 2012
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3368090/
https://ncbi.nlm.nih.gov/pubmed/22521571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.humimm.2012.03.005
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