Hematopoietic stem cells lacking Ott1 display aspects associated with aging and are unable to maintain quiescence during proliferative stress

Aging degrades hematopoietic stem cell (HSC) functions, including stress response; however, the involved molecular pathways are incompletely defined. Murine BM conditionally deleted for One-Twenty-Two-1 (Ott1), is able to maintain lifelong hematopoiesis and has preserved numbers of long-term HSCs, y...

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Bibliografiske detaljer
Main Authors: Xiao, Nan, Jani, Kaushal, Morgan, Kelly, Okabe, Rachel, Cullen, Dana E., Jesneck, Jonathan L., Raffel, Glen D.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2012
Fag:
Hematopoiesis and Stem Cells
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3367894/
https://ncbi.nlm.nih.gov/pubmed/22490678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-01-403089
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