Chemical coupling of thiolated chitosan to preformed liposomes improves mucoadhesive properties

AIM: To develop mucoadhesive liposomes by anchoring the polymer chitosan-thioglycolic acid (chitosan-TGA) to the liposomal surface to target intestinal mucosal membranes. METHODS: Liposomes consisting of phosphatidylcholine (POPC) and a maleimide-functionalized lipid were incubated with chitosan-TGA...

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Detalhes bibliográficos
Main Authors: Gradauer, Kerstin, Vonach, Caroline, Leitinger, Gerd, Kolb, Dagmar, Fröhlich, Eleonore, Roblegg, Eva, Bernkop-Schnürch, Andreas, Prassl, Ruth
Formato: Artigo
Idioma:Inglês
Publicado em: Dove Medical Press 2012
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Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3367495/
https://ncbi.nlm.nih.gov/pubmed/22679365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S29980
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