Novel mechanisms of early upper and lower urinary tract patterning regulated by RetY1015 docking tyrosine in mice

Mutations in the receptor tyrosine kinase RET are associated with congenital anomalies of kidneys or urinary tract (CAKUT). RET tyrosine Y1015 is the docking site for PLCγ, a major regulator of RET signaling. Abrogating signaling via Y1015 causes CAKUT that are markedly different than renal agenesis...

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Main Authors: Hoshi, Masato, Batourina, Ekatherina, Mendelsohn, Cathy, Jain, Sanjay
Format: Artigo
Jezik:Inglês
Izdano: Company of Biologists 2012
Teme:
Research Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3367447/
https://ncbi.nlm.nih.gov/pubmed/22627285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.078667
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