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Junctional protein regulation by sphingosine kinase 2 contributes to blood–brain barrier protection in hypoxic preconditioning-induced cerebral ischemic tolerance

Protection of the blood–brain barrier (BBB) is correlated with improved outcome in stroke. Sphingosine kinase (SphK)-directed production of sphingosine-1-phosphate, which we previously documented as being vital to preconditioning-induced stroke protection, mediates peripheral vascular integrity via...

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Detalhes bibliográficos
Main Authors: Wacker, Bradley K, Freie, Angela B, Perfater, Jennifer L, Gidday, Jeffrey M
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3367228/
https://ncbi.nlm.nih.gov/pubmed/22314269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2012.3
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