Lactate, a product of glycolytic metabolism, inhibits histone deacetylase activity and promotes changes in gene expression

Chemical inhibitors of histone deacetylase (HDAC) activity are used as experimental tools to induce histone hyperacetylation and deregulate gene transcription, but it is not known whether the inhibition of HDACs plays any part in the normal physiological regulation of transcription. Using both in vi...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Latham, Tom, Mackay, Logan, Sproul, Duncan, Karim, Muhammed, Culley, Jayne, Harrison, David J, Hayward, Larry, Langridge-Smith, Pat, Gilbert, Nick, Ramsahoye, Bernard H
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2012
Schlagworte:
Gene Regulation, Chromatin and Epigenetics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3367171/
https://ncbi.nlm.nih.gov/pubmed/22323521
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks066
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