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Dopamine pathway loss in nucleus accumbens and ventral tegmental area predicts apathetic behavior in MPTP-lesioned monkeys

Apathy, primarily defined as a lack of motivation, commonly occurs in people with Parkinson disease (PD). Although dysfunction of basal ganglia pathways may contribute to apathy, the role of dopamine remains largely unknown. We investigated the role of dopaminergic pathways in the manifestation of a...

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Detalhes bibliográficos
Main Authors: Brown, CA, Campbell, MC, Karimi, M, Tabbal, SD, Loftin, SK, Tian, LL, Moerlein, SM, Perlmutter, JS
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3367030/
https://ncbi.nlm.nih.gov/pubmed/22579525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.expneurol.2012.04.025
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