On the Mechanism of Action of SJ-172550 in Inhibiting the Interaction of MDM4 and p53

SJ-172550 (1) was previously discovered in a biochemical high throughput screen for inhibitors of the interaction of MDMX and p53 and characterized as a reversible inhibitor (J. Biol. Chem. 2010; 285∶10786). Further study of the biochemical mode of action of 1 has shown that it acts through a compli...

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Detalhes bibliográficos
Main Authors: Bista, Michal, Smithson, David, Pecak, Aleksandra, Salinas, Gabriella, Pustelny, Katarzyna, Min, Jaeki, Pirog, Artur, Finch, Kristin, Zdzalik, Michal, Waddell, Brett, Wladyka, Benedykt, Kedracka-Krok, Sylwia, Dyer, Michael A., Dubin, Grzegorz, Guy, R. Kiplin
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3366986/
https://ncbi.nlm.nih.gov/pubmed/22675482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0037518
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