In Vivo Detection of Amyloid-β Deposits Using Heavy Chain Antibody Fragments in a Transgenic Mouse Model for Alzheimer's Disease

This study investigated the in vivo properties of two heavy chain antibody fragments (V(H)H), ni3A and pa2H, to differentially detect vascular or parenchymal amyloid-β deposits characteristic for Alzheimer's disease and cerebral amyloid angiopathy. Blood clearance and biodistribution including...

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Détails bibliographiques
Auteurs principaux: Nabuurs, Rob J. A., Rutgers, Kim S., Welling, Mick M., Metaxas, Athanasios, de Backer, Maaike E., Rotman, Maarten, Bacskai, Brian J., van Buchem, Mark A., van der Maarel, Silvère M., van der Weerd, Louise
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2012
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3366949/
https://ncbi.nlm.nih.gov/pubmed/22675537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0038284
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