Caution in Interpreting Results from Imputation Analysis When Linkage Disequilibrium Extends over a Large Distance: A Case Study on Venous Thrombosis

By applying an imputation strategy based on the 1000 Genomes project to two genome-wide association studies (GWAS), we detected a susceptibility locus for venous thrombosis on chromosome 11p11.2 that was missed by previous GWAS analyses that had been conducted on the same datasets. A comprehensive l...

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Detalhes bibliográficos
Main Authors: Germain, Marine, Saut, Noémie, Oudot-Mellakh, Tiphaine, Letenneur, Luc, Dupuy, Anne-Marie, Bertrand, Marion, Alessi, Marie-Christine, Lambert, Jean-Charles, Zelenika, Diana, Emmerich, Joseph, Tiret, Laurence, Cambien, Francois, Lathrop, Mark, Amouyel, Philippe, Morange, Pierre-Emmanuel, Trégouët, David-Alexandre
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3366937/
https://ncbi.nlm.nih.gov/pubmed/22675575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0038538
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