Enoxacin Directly Inhibits Osteoclastogenesis without Inducing Apoptosis

Enoxacin has been identified as a small molecule inhibitor of binding between the B2-subunit of vacuolar H+-ATPase (V-ATPase) and microfilaments. It inhibits bone resorption by calcitriol-stimulated mouse marrow cultures. We hypothesized that enoxacin acts directly and specifically on osteoclasts by...

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Detalhes bibliográficos
Main Authors: Toro, Edgardo J., Zuo, Jian, Ostrov, David A., Catalfamo, Dana, Bradaschia-Correa, Vivian, Arana-Chavez, Victor, Caridad, Aliana R., Neubert, John K., Wronski, Thomas J., Wallet, Shannon M., Holliday, L. Shannon
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3366803/
https://ncbi.nlm.nih.gov/pubmed/22474295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.280511
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