Sequence Variation in Promoter of Ica1 Gene, Which Encodes Protein Implicated in Type 1 Diabetes, Causes Transcription Factor Autoimmune Regulator (AIRE) to Increase Its Binding and Down-regulate Expression

ICA69 (islet cell autoantigen 69 kDa) is a protein implicated in type 1 diabetes mellitus in both the non-obese diabetic (NOD) mouse model and humans. ICA69 is encoded by the Ica1 gene on mouse chromosome 6 A1-A2. We previously reported reduced ICA69 expression in the thymus of NOD mice compared wit...

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Detalhes bibliográficos
Main Authors: Bonner, Samantha M., Pietropaolo, Susan L., Fan, Yong, Chang, Yigang, Sethupathy, Praveen, Morran, Michael P., Beems, Megan, Giannoukakis, Nick, Trucco, Giuliana, Palumbo, Michael O., Solimena, Michele, Pugliese, Alberto, Polychronakos, Constantin, Trucco, Massimo, Pietropaolo, Massimo
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3366781/
https://ncbi.nlm.nih.gov/pubmed/22447927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.319020
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