Studies on the Synthesis of Derivatives of Marine-Derived Bostrycin and Their Structure-Activity Relationship against Tumor Cells

A series of new derivatives (5–29) of marine-derived bostrycin (1) were synthesized. The in vitro cytotoxic activities of all compounds were evaluated against MCF-7, MDA-MB-435, A549, HepG2, HCT-116 and MCF-10A cells using the MTT method. The compounds 7, 8, 22, 23, 25, 28 and 29 of the total showed...

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Detalhes bibliográficos
Main Authors: Chen, Hong, Zhong, Lili, Long, Yuhua, Li, Jia, Wu, Jueheng, Liu, Lan, Chen, Shengping, Lin, Yongcheng, Li, Mengfeng, Zhu, Xun, She, Zhigang
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3366684/
https://ncbi.nlm.nih.gov/pubmed/22690152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/md10040932
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