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Activation of resorption in fatigue-loaded bone involves both apoptosis and active pro-osteoclastogenic signaling by distinct osteocyte populations

Osteocyte apoptosis is required to initiate osteoclastic bone resorption following fatigue-induced microdamage in vivo; however, it is unclear whether apoptotic osteocytes also produce the signals that induce osteoclast differentiation. We determined the spatial and temporal patterns of osteocyte ap...

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Detalhes bibliográficos
Main Authors: Kennedy, Oran D., Herman, Brad C., Laudier, Damien M., Majeska, Robert J., Sun, Hui B., Schaffler, Mitchell B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3366436/
https://ncbi.nlm.nih.gov/pubmed/22342796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bone.2012.01.025
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