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Polymer nanoparticle-mediated delivery of microRNA inhibition and alternative splicing
The crux of current RNA-based therapeutics relies on association of synthetic nucleic acids with cellular RNA targets. Antisense oligonucleotide binding to mature microRNA and splicing junctions on pre-mRNA represent methods of gene therapy that respectively inhibit microRNA-mediated gene regulation...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3366258/ https://ncbi.nlm.nih.gov/pubmed/22482958 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/mp300081s |
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