The double life of MULE in preeclamptic and IUGR placentae

The E3 ubiquitin ligase MULE (Mcl-1 Ubiquitin Ligases E3) targets myeloid cell leukemia factor 1 (Mcl-1) and tumor suppressor p53 for proteasomal degradation. Although Mcl-1 and p53 have been implicated in trophoblast cell death in preeclampsia (PE) and intrauterine growth restriction (IUGR), the me...

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Autors principals: Rolfo, A, Garcia, J, Todros, T, Post, M, Caniggia, I
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2012
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3366078/
https://ncbi.nlm.nih.gov/pubmed/22552282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2012.44
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