Nucleophosmin (NPM1/B23) Interacts with Activating Transcription Factor 5 (ATF5) Protein and Promotes Proteasome- and Caspase-dependent ATF5 Degradation in Hepatocellular Carcinoma Cells

Nucleophosmin (NPM1/B23) and the activating transcription factor 5 (ATF5) are both known to subject to cell type-dependent regulation. NPM1 is expressed weakly in hepatocytes and highly expressed in hepatocellular carcinomas (HCC) with a clear correlation between enhanced NPM1 expression and increas...

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Hlavní autoři: Liu, Xijun, Liu, Dan, Qian, Dongmeng, Dai, Jenny, An, Yi, Jiang, Shaoyan, Stanley, Bruce, Yang, Jinming, Wang, Bin, Liu, Xinyuan, Liu, David X.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2012
Témata:
Gene Regulation
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3365995/
https://ncbi.nlm.nih.gov/pubmed/22528486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.363622
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