Demethylation of the Coding Region Triggers the Activation of the Human Testis-Specific PDHA2 Gene in Somatic Tissues

Human PDHA2 is a testis-specific gene that codes for the E(1)α subunit of Pyruvate Dehydrogenase Complex (PDC), a crucial enzyme system in cell energy metabolism. Since activation of the PDHA2 gene in somatic cells could be a new therapeutic approach for PDC deficiency, we aimed to identify the regu...

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Bibliographic Details
Main Authors: Pinheiro, Ana, Nunes, Maria João, Milagre, Inês, Rodrigues, Elsa, Silva, Maria João, de Almeida, Isabel Tavares, Rivera, Isabel
Format: Artigo
Language:Inglês
Published: Public Library of Science 2012
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3365900/
https://ncbi.nlm.nih.gov/pubmed/22675509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0038076
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