Endocrine Parameters and Phenotypes of the Growth Hormone Receptor Gene Disrupted (GHR−/−) Mouse

Disruption of the GH receptor (GHR) gene eliminates GH-induced intracellular signaling and, thus, its biological actions. Therefore, the GHR gene disrupted mouse (GHR−/−) has been and is a valuable tool for helping to define various parameters of GH physiology. Since its creation in 1995, this mouse...

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Autors principals: List, Edward O., Sackmann-Sala, Lucila, Berryman, Darlene E., Funk, Kevin, Kelder, Bruce, Gosney, Elahu S., Okada, Shigeru, Ding, Juan, Cruz-Topete, Diana, Kopchick, John J.
Format: Artigo
Idioma:Inglês
Publicat: Endocrine Society 2011
Matèries:
Reviews
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3365798/
https://ncbi.nlm.nih.gov/pubmed/21123740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/er.2010-0009
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