Dopamine-derived Quinones Affect the Structure of the Redox Sensor DJ-1 through Modifications at Cys-106 and Cys-53

The physiological role of DJ-1, a protein involved in familial Parkinson disease is still controversial. One of the hypotheses proposed indicates a sensor role for oxidative stress, through oxidation of a conserved cysteine residue (Cys-106). The association of DJ-1 mutations with Parkinson disease...

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Detalhes bibliográficos
Main Authors: Girotto, Stefania, Sturlese, Mattia, Bellanda, Massimo, Tessari, Isabella, Cappellini, Rekha, Bisaglia, Marco, Bubacco, Luigi, Mammi, Stefano
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3365698/
https://ncbi.nlm.nih.gov/pubmed/22431735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.311589
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