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Uricases as therapeutic agents to treat refractory gout: Current states and future directions
Treatment of refractory gout remains a challenge on drug development. While pegloticase, a recombinant mammalian uricase modified with monomethoxyl-poly(ethylene glycol) (mPEG) is effective in treating refractory gout, after continued treatment for three months biweekly at a therapeutic dose of 0.14...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3365602/ https://ncbi.nlm.nih.gov/pubmed/22665944 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ddr.20493 |
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