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Gene regulation via excitation and BDNF is mediated by induction and phosphorylation of the Etv1 transcription factor in cerebellar granule cells

In maturing postnatal cerebellar granule cells, the Etv1/Er81 transcription factor is induced by sequential activity-dependent mechanisms through stimulation of AMPA and NMDA receptors, voltage-dependent Nav1.2 Na(+) channels, and voltage-dependent Ca(2+) channels. Etv1 then up-regulates a battery o...

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Sonraí Bibleagrafaíochta
Main Authors: Abe, Haruka, Okazawa, Makoto, Nakanishi, Shigetada
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2012
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3365191/
https://ncbi.nlm.nih.gov/pubmed/22586091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1206418109
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