A Proton Leak Current through the Cardiac Sodium Channel Is Linked to Mixed Arrhythmia and the Dilated Cardiomyopathy Phenotype

Cardiac Na(+) channels encoded by the SCN5A gene are essential for initiating heart beats and maintaining a regular heart rhythm. Mutations in these channels have recently been associated with atrial fibrillation, ventricular arrhythmias, conduction disorders, and dilated cardiomyopathy (DCM). We in...

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Detalhes bibliográficos
Main Authors: Gosselin-Badaroudine, Pascal, Keller, Dagmar I., Huang, Hai, Pouliot, Valérie, Chatelier, Aurélien, Osswald, Stefan, Brink, Marijke, Chahine, Mohamed
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3365008/
https://ncbi.nlm.nih.gov/pubmed/22675453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0038331
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