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Solvent Removal and Spore Inactivation Directly in Dispensing Vials with Supercritical Carbon Dioxide and Sterilant
A process is described using supercritical carbon dioxide to extract organic solvents from drug solutions contained in 30-mL serum vials. We report drying times of less than 1 h with quantitative recovery of sterile drug. A six-log reduction of three spore types used as biological indicators is achi...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Springer US
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3364381/ https://ncbi.nlm.nih.gov/pubmed/22528546 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12249-012-9777-4 |
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