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Fractionation of a Herbal Antidiarrheal Medicine Reveals Eugenol as an Inhibitor of Ca(2+)-Activated Cl(−) Channel TMEM16A
The Ca(2+)-activated Cl(−) channel TMEM16A is involved in epithelial fluid secretion, smooth muscle contraction and neurosensory signaling. We identified a Thai herbal antidiarrheal formulation that inhibited TMEM16A Cl(−) conductance. C18-reversed-phase HPLC fractionation of the herbal formulation...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Public Library of Science
2012
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3364195/ https://ncbi.nlm.nih.gov/pubmed/22666439 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0038030 |
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