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Evaluation of cell death mechanisms induced by the vascular disrupting agent OXi4503 during a phase I clinical trial
BACKGROUND: OXi4503 is a tubulin-binding vascular disrupting agent that has recently completed a Cancer Research UK-sponsored phase I trial. Preclinical studies demonstrated early drug-induced apoptosis in tumour endothelial cells at 1–3 h and secondary tumour cell necrosis between 6 and 72 h. METHO...
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| Główni autorzy: | , , , , , , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
Nature Publishing Group
2012
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3364117/ https://ncbi.nlm.nih.gov/pubmed/22538971 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2012.165 |
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