The Yeast Ubr1 Ubiquitin Ligase Participates in a Prominent Pathway That Targets Cytosolic Thermosensitive Mutants for Degradation

Mutations causing protein misfolding and proteolysis are associated with many genetic diseases. The degradation of these aberrant proteins typically is mediated by protein-quality control pathways that recognize misfolded domains. Several E3 ubiquitin ligases have been shown to target cytosolic misf...

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Autors principals: Khosrow-Khavar, Farzin, Fang, Nancy N., Ng, Alex H. M., Winget, Jason M., Comyn, Sophie A., Mayor, Thibault
Format: Artigo
Idioma:Inglês
Publicat: Genetics Society of America 2012
Matèries:
Investigations
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3362944/
https://ncbi.nlm.nih.gov/pubmed/22670231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/g3.111.001933
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