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DNA Polymerase ζ Is a Major Determinant of Resistance to Platinum-Based Chemotherapeutic Agents

Oxaliplatin, satraplatin, and picoplatin are cisplatin analogs that interact with DNA forming intrastrand and interstrand DNA cross-links (ICLs). Replicative bypass of cisplatin DNA adducts requires the cooperative actions of at least three translesion DNA synthesis (TLS) polymerases: Polη, REV1, an...

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Hlavní autoři: Sharma, Shilpy, Shah, Nicholas A., Joiner, Ariell M., Roberts, Katelyn H., Canman, Christine E.
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society for Pharmacology and Experimental Therapeutics 2012
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3362893/
https://ncbi.nlm.nih.gov/pubmed/22387291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.111.076828
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