Pituitary Adenylate Cyclase-Activating Polypeptide Causes Tyrosine Phosphorylation of the Epidermal Growth Factor Receptor in Lung Cancer Cells

Pituitary adenylate cyclase-activating polypeptide (PACAP) is an autocrine growth factor for some lung cancer cells. The activated PACAP receptor (PAC1) causes phosphatidylinositol turnover, elevates cAMP, and increases the proliferation of lung cancer cells. PAC1 and epidermal growth factor recepto...

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Bibliographic Details
Main Authors: Moody, Terry W., Osefo, Nauramy, Nuche-Berenguer, Bernardo, Ridnour, Lisa, Wink, David, Jensen, Robert T.
Format: Artigo
Language:Inglês
Published: The American Society for Pharmacology and Experimental Therapeutics 2012
Subjects:
Cellular and Molecular
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3362890/
https://ncbi.nlm.nih.gov/pubmed/22389426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.111.190033
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