Pituitary Adenylate Cyclase-Activating Polypeptide Causes Tyrosine Phosphorylation of the Epidermal Growth Factor Receptor in Lung Cancer Cells

Pituitary adenylate cyclase-activating polypeptide (PACAP) is an autocrine growth factor for some lung cancer cells. The activated PACAP receptor (PAC1) causes phosphatidylinositol turnover, elevates cAMP, and increases the proliferation of lung cancer cells. PAC1 and epidermal growth factor recepto...

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Main Authors: Moody, Terry W., Osefo, Nauramy, Nuche-Berenguer, Bernardo, Ridnour, Lisa, Wink, David, Jensen, Robert T.
Formáid: Artigo
Teanga:Inglês
Foilsithe: The American Society for Pharmacology and Experimental Therapeutics 2012
Ábhair:
Cellular and Molecular
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3362890/
https://ncbi.nlm.nih.gov/pubmed/22389426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.111.190033
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