Sequential irinotecan hydrochloride/S-1 for S-1-resistant inoperable gastric cancer: A feasibility study

Irinotecan hydrochloride (CPT-11) is reported to be involved in the downregulation of thymidylate synthase (TS), a target molecule of 5-fluorouracil (5-FU) and oral fluoropyrimidine S-1. Therefore, we hypothesized that a preceding administration of CPT-11 against S-1-resistant tumors may recover sen...

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Autors principals: TAKAHATA, TAKENORI, ITOH, JUGOH, SATOH, TAROH, ISHIGURO, ATSUSHI, MATSUMOTO, YOSHIFUMI, TANAKA, SATOSHI, SAITOH, SOH, TOHNO, HIROSHI, FUKUDA, SHINSAKU, SAIJO, YASUO, SAKATA, YUH
Format: Artigo
Idioma:Inglês
Publicat: D.A. Spandidos 2012
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3362594/
https://ncbi.nlm.nih.gov/pubmed/22740861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ol.2011.435
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