Acquired/intratumoral mutation of KRAS during metastatic progression of colorectal carcinogenesis

Mutations at codons 12 and 13 of the KRAS gene have been identified as level I predictive biomarkers against the treatment of advanced colorectal cancer with anti-epidermal growth factor receptor (EGFR) monoclonal antibodies. It is thought that the genetic analysis of KRAS mutations associated with...

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Autori principali: OTSUKA, KAZUNORI, SATOYOSHI, RIKA, NANJO, HIROSHI, MIYAZAWA, HIDEAKI, ABE, YUKI, TANAKA, MASAMITSU, YAMAMOTO, YUZO, SHIBATA, HIROYUKI
Natura: Artigo
Lingua:Inglês
Pubblicazione: D.A. Spandidos 2011
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3362436/
https://ncbi.nlm.nih.gov/pubmed/22740969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ol.2011.543
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