Silencing Notch-1 induces apoptosis and increases the chemosensitivity of prostate cancer cells to docetaxel through Bcl-2 and Bax

Although docetaxel-based chemotherapy is therapeutically efficacious, drug resistance often leads to treatment failure in castration-resistant prostate cancer patients. The Notch signaling pathway plays a key role in prostate development and prostate cancer. We investigated whether silencing Notch-1...

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Hlavní autoři: Ye, Qi-Fa, Zhang, Yi-Chuan, Peng, Xiao-Qing, Long, Zhi, Ming, Ying-Zi, He, Le-Ye
Médium: Artigo
Jazyk:Inglês
Vydáno: D.A. Spandidos 2012
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3362393/
https://ncbi.nlm.nih.gov/pubmed/22741011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ol.2012.572
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