Activating autoantibodies to the angiotensin II type I receptor play an important role in mediating hypertension in response to adoptive transfer of CD4(+) T lymphocytes from placental ischemic rats

Hypertension in rats with chronic placental ischemia (reduced uterine perfusion pressure, RUPP) is associated with elevated inflammatory cytokines, agonistic autoantibodies to the angiotensin II type I receptor (AT1-AA) and CD4(+) T cells; all of which are elevated in preclamptic women. Additionally...

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Main Authors: Novotny, Sarah Richards, Wallace, Kedra, Heath, Judith, Moseley, Janae, Dhillon, Pushpinder, Weimer, Abram, Wallukat, Gerd, Herse, Florian, Wenzel, Katrin, Martin, James N., Dechend, Ralf, LaMarca, Babbette
Format: Artigo
Sprog:Inglês
Udgivet: American Physiological Society 2012
Fag:
Fluid and Electrolyte Homeostasis
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3362148/
https://ncbi.nlm.nih.gov/pubmed/22461177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpregu.00623.2011
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