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Preproendothelin-1 expression is negatively regulated by IFNγ during hepatic stellate cell activation
Endothelin-1 (ET-1), a powerful vasoconstrictor peptide, is produced by activated hepatic stellate cells (HSC) and promotes cell proliferation, fibrogenesis, and contraction, the latter of which has been thought to be mechanistically linked to portal hypertension in cirrhosis. Interferon-γ (IFNγ), a...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Physiological Society
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3362071/ https://ncbi.nlm.nih.gov/pubmed/22301113 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00359.2011 |
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