CB(1) antagonism restores hepatic insulin sensitivity without normalization of adiposity in diet-induced obese dogs

The endocannabinoid system is highly implicated in the development of insulin resistance associated with obesity. It has been shown that antagonism of the CB(1) receptor improves insulin sensitivity (S(I)). However, it is unknown whether this improvement is due to the direct effect of CB(1) blockade...

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Auteurs principaux: Kim, Stella P., Woolcott, Orison O., Hsu, Isabel R., Stefanoski, Darko, Harrison, L. Nicole, Zheng, Dan, Lottati, Maya, Kolka, Cathryn, Catalano, Karyn J., Chiu, Jenny D., Kabir, Morvarid, Ionut, Viorica, Bergman, Richard N., Richey, Joyce M.
Format: Artigo
Langue:Inglês
Publié: American Physiological Society 2012
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Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3361982/
https://ncbi.nlm.nih.gov/pubmed/22374758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00496.2011
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