Asiatic Acid Attenuates Infarct Volume, Mitochondrial Dysfunction and Matrix Metalloproteinase-9 Induction after Focal Cerebral Ischemia

BACKGROUND AND PURPOSE: Asiatic acid (AA) has been shown to attenuate cerebral infarction in a mouse model of focal ischemia and shows promise as a neuroprotective stroke therapy. To facilitate translation of these findings to clinical studies, we determined pharmacokinetics, a dose response relatio...

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Hauptverfasser: Lee, Ki Yong, Bae, Ok-Nam, Serfozo, Kelsey, Kelsey, Siamk, Moussa, Ahmad, Reeves, Mathew, Rumbeiha, Wilson, Fitzgerald, Scott D., Stein, Gray, Baek, Seung-Hoon, Goudreau, John, Kassab, Mounzer, Majid, Arshad
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3361557/
https://ncbi.nlm.nih.gov/pubmed/22511009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/STROKEAHA.111.639427
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