Loss of epigenetic modification driven by the Foxp3 transcription factor leads to regulatory T cell insufficiency

Regulatory T (Treg) cells, driven by the Foxp3 transcription factor, are responsible for limiting autoimmunity and chronic inflammation. We showed that a well-characterized Foxp3(gfp) reporter mouse, which expresses an N-terminal GFP-Foxp3 fusion protein, is a hypomorph that causes profoundly accele...

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Main Authors: Bettini, Matthew L., Pan, Fan, Bettini, Maria, Finkelstein, David, Rehg, Jerold E., Floess, Stefan, Bell, Bryan D., Ziegler, Steven F., Huehn, Jochen, Pardoll, Drew M., Vignali, Dario A.A.
Format: Artigo
Jezik:Inglês
Izdano: 2012
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3361541/
https://ncbi.nlm.nih.gov/pubmed/22579476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2012.03.020
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