Klotho-beta overexpression as a novel target for suppressing proliferation and fibroblast growth factor receptor-4 signaling in hepatocellular carcinoma

BACKGROUND: We had previously demonstrated overexpression of fibroblast growth factor receptor-4 (FGFR4) in hepatocellular carcinoma (HCC). However, additional molecular mechanisms resulting in amplified FGFR4 signaling in HCC remain under-studied. Here, we studied the mechanistic role of its co-rec...

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Autors principals: Poh, Weijie, Wong, Winnie, Ong, Huimin, Aung, Myat Oo, Lim, Seng Gee, Chua, Boon Tin, Ho, Han Kiat
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2012
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3361496/
https://ncbi.nlm.nih.gov/pubmed/22439738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-11-14
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