Anti-malarial activity of geldanamycin derivatives in mice infected with Plasmodium yoelii

BACKGROUND: Geldanamycin (GA), a benzoquinone ansamycin antibiotic has been shown in vitro to possess anti-plasmodial activity. Pharmacological activity of this drug is attributed to its ability to inhibit PfHSP90. The parasite growth arrest has been shown to be due to drug-induced blockage of the t...

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Detaylı Bibliyografya
Asıl Yazarlar: Mout, Rubul, Xu, Zhi-Dong, Wolf, Angela K H, Jo Davisson, Vincent, Jarori, Gotam K
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BioMed Central 2012
Konular:
Research
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3361485/
https://ncbi.nlm.nih.gov/pubmed/22361388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2875-11-54
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