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Dynamic regulatory on/off minimization for biological systems under internal temporal perturbations

BACKGROUND: Flux balance analysis (FBA) together with its extension, dynamic FBA, have proven instrumental for analyzing the robustness and dynamics of metabolic networks by employing only the stoichiometry of the included reactions coupled with adequately chosen objective function. In addition, und...

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Autori principali: Kleessen, Sabrina, Nikoloski, Zoran
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3361480/
https://ncbi.nlm.nih.gov/pubmed/22409942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1752-0509-6-16
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