Genome-wide association and functional studies identify the DOT1L gene to be involved in cartilage thickness and hip osteoarthritis

Hip osteoarthritis (HOA) is one of the most disabling and common joint disorders with a large genetic component that is, however, still ill-defined. To date, genome-wide association studies (GWAS) in osteoarthritis (OA) and specifically in HOA have yielded only few loci, which is partly explained by...

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Main Authors: Castaño Betancourt, Martha C., Cailotto, Frederic, Kerkhof, Hanneke J., Cornelis, Frederique M. F., Doherty, Sally A., Hart, Deborah J., Hofman, Albert, Luyten, Frank P., Maciewicz, Rose A., Mangino, Massimo, Metrustry, Sarah, Muir, Kenneth, Peters, Marjolein J., Rivadeneira, Fernando, Wheeler, Maggie, Zhang, Weiya, Arden, Nigel, Spector, Tim D., Uitterlinden, Andre G., Doherty, Michael, Lories, Rik J. U., Valdes, Ana M., van Meurs, Joyce B. J.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2012
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3361426/
https://ncbi.nlm.nih.gov/pubmed/22566624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1119899109
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