Naphthoquinones from Onosma paniculata Induce Cell-Cycle Arrest and Apoptosis in Melanoma Cells

[Image: see text] Activity-guided fractionation of a petroleum ether-soluble extract of the roots of Onosma paniculata, which has been shown to affect the cell cycle and to induce apoptosis in melanoma cells, led to the isolation of several shikonin derivatives, namely, β-hydroxyisovalerylshikonin (...

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Detalhes bibliográficos
Main Authors: Kretschmer, Nadine, Rinner, Beate, Deutsch, Alexander J. A., Lohberger, Birgit, Knausz, Heike, Kunert, Olaf, Blunder, Martina, Boechzelt, Herbert, Schaider, Helmut, Bauer, Rudolf
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society and American Society of Pharmacognosy 2012
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3361261/
https://ncbi.nlm.nih.gov/pubmed/22530779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/np2006499
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