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Unlocking the binding and reaction mechanism of hydroxyurea substrates as biological nitric oxide donors
Hydroxyurea is the only FDA approved treatment of sickle cell disease. It is believed the primary mechanism of action is associated with the pharmacological elevation of nitric oxide in the blood; however, the exact details of this are still unclear. In the current work, we investigate the atomic le...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2012
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3360818/ https://ncbi.nlm.nih.gov/pubmed/22519847 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ci300035c |
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