Accumulation of Exogenous Amyloid-Beta Peptide in Hippocampal Mitochondria Causes Their Dysfunction: A Protective Role for Melatonin

Amyloid-beta (Aβ) pathology is related to mitochondrial dysfunction accompanied by energy reduction and an elevated production of reactive oxygen species (ROS). Monomers and oligomers of Aβ have been found inside mitochondria where they accumulate in a time-dependent manner as demonstrated in transg...

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Main Authors: Rosales-Corral, Sergio, Acuna-Castroviejo, Dario, Tan, Dun Xian, López-Armas, Gabriela, Cruz-Ramos, José, Munoz, Rubén, Melnikov, Valery G., Manchester, Lucien C., Reiter, Russel J.
Formato: Artigo
Idioma:Inglês
Publicado: Hindawi Publishing Corporation 2012
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3359765/
https://ncbi.nlm.nih.gov/pubmed/22666521
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2012/843649
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